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Journal of Bioactive and Compatible Polymers
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A New Class II Poly ({epsilon}-Caprolactone)-Silica Hybrid: Synthesis and In Vitro Apatite Forming Ability

David Eglin

Division of Chemistry, Interdisciplinary Biomedical Research Centre, The Nottingham Trent University, Nottingham NG11 8NS, UK

Carole C. Perry

Division of Chemistry, Interdisciplinary Biomedical Research Centre, The Nottingham Trent University, Nottingham NG11 8NS, UK, carole.perry{at}ntu.ac.uk

Saad A. M. Ali

Smith & Nephew Group Research Centre, York Science Park, Heslington, York YO10 5DF, UK

The synthesis of a new class II poly({epsilon}-caprolactone)-silica hybrid has been carried out using tin (II) 2-ethylhexanoate as the catalyst. Swelling behaviour, solid state 29 Si NMR and other techniques indicate the formation of interconnected organic-inorganic materials. An in vitro apatite forming ability test performed on this new class of material compared with an equivalent class I poly({epsilon}-caprolactone)-silica sol-gel hybrid (identical silica content) showed the absence of apatite formation on the class II hybrid surface and calcium phosphate precipitation on the class I hybrid surface. This effect may be linked to less silicic acid being released in the simulated body fluid for the class II hybrid compared to the class I hybrid.

Key Words: poly({epsilon}-caprolactone) • silica • hybrid • in vitro osteoconductivity

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 5, 437-454 (2005)
DOI: 10.1177/0883911505057469
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