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Preparation of Polyelectrolyte-Containing Nanofibers by Electrospinning in the Presence of a Non-Ionogenic Water-Soluble Polymer

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria, manolova{at}polymer.bas.bg

D. Paneva

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

I. Rashkov

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria, rashkov{at}polymer.bas.bg

The first successful preparation of nanofibers of a polyampholyte (N-carboxyethylchitosan) by electrospinning was achieved by adding a non-ionogenic water-soluble polymer to the spinning solution. Using this approach, other polyelectrolytes, poly(2-acryloylamido-2-methylpropanesulphonic acid) (PAMPS), and copolymers of 2-acryloylamido-2-methylpropane-sulphonic acid (AMPS) and acrylic acid [P(AMPS-co-AA)] were also electrospun into nanofibers. The non-ionogenic water-soluble polymers were polyacrylamide (PAAm) and poly(vinyl alcohol) (PVA). The average diameters of the electrospun nanofibers were in the range 50-260nm. The average diameter of the nanofibers significantly decreased with increasing polyelectrolyte content. The electrospun nanofibers were crosslinked by heat treatment at 100, 120 or 150°C for the N-carboxyethylchitosan/PAAm pair and at 90°C in the case of P(AMPS-co-AA)/PVA. The presence of an ionizable low-molecular-weight compound (7-iodo-8-hydroxyquinoline-5-sulphonic acid, SQ) led to a more than two-fold decrease in the diameter of the nanofibers and to the appearance of defects. The SQ-containing nanofibers showed antimicrobial activity against pathogenic microorganisms.

Key Words: electrospinning • water-resistant nanofibers • polyelectrolytes • non-ionogenic polymers • heat-induced crosslinking • N-carboxyethylchitosan • PAMPS • AMPS copolymers • polyacrylamide • poly(vinyl alcohol) • antimicrobial activity

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 5, 419-435 (2005)
DOI: 10.1177/0883911505057447


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