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Journal of Bioactive and Compatible Polymers
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Mesenchymal Stem Cells on Plasma-Deposited Acrylic Acid Coatings: An In Vitro Investigation to Improve Biomaterial Performance in Bone Reconstruction

M. Mattioli-Belmonte

Istituto di Morfologia Umana Normale, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy, belmonte{at}med.univpm.it

G. Lucarini

Istituto di Morfologia Umana Normale, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

L. Virgili

Istituto di Morfologia Umana Normale, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

G. Biagini

Istituto di Morfologia Umana Normale, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

L. Detomaso

Dipartimento di Chimica, Università degli Studi di Bari, Via Orabona 4, 70126 Bari, Italy

P. Favia

Dipartimento di Chimica, Università degli Studi di Bari, Via Orabona 4, 70126 Bari, Italy

R. D’Agostino

Dipartimento di Chimica, Università degli Studi di Bari, Via Orabona 4, 70126 Bari, Italy

R. Gristina

Istituto di Metodologie Inorganiche e dei Plasmi (IMIP)-CNR, c/o Università degli Studi di Bari, Via Orabona 4, 70126 Bari, Italy

A. Gigante

Dipartimento di Patologia Molecolare e Terapie Innovative, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

C. Bevilacqua

Dipartimento di Patologia Molecolare e Terapie Innovative, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

In this in vitro investigation of a heterogeneous range of bio-functional and modulatory performances of mesenchymal stem cells (MSCs) grown on two plasma-deposited acrylic acid (pdAA) coatings, which differed in chemical characteristics, a view of their potential utility as hybrid scaffolds for bone tissue engineering was obtained. The in vitro behavior of MSCs was compared to that of MG-63 cells, an osteoblast-like cell line that is commonly used to test biocompatibility of materials intended for bone-tissue interface. The coatings exerted a greater stimulus on MSCs and on MG-63 cells in comparison with control cultures. Both studied coatings exhibited satisfactory compatibility and modulatory effects on MSCs, thus they may be suitable for use in 2D or 3D scaffolds for bone tissue reconstruction.

Key Words: plasma-deposited coatings • acrylic acid • polymer surface modification • mesenchymal stem cells • cell behavior • bone scaffolds

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 4, 343-360 (2005)
DOI: 10.1177/0883911505055159
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