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Journal of Bioactive and Compatible Polymers
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Perspectives on: Strategies to Fabricate Starch-based Hydrogels with Potential Biomedical Applications

Li-Ming Zhang

School of Chemistry and Chemical Engineering and Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Zhongshan (Sun Yat-sen) University, Guangzhou 510275, P.R. China, ceszhlm{at}zsu.edu.cn

Chuan Yang

Second Affiliated Hospital, Zhongshan (Sun Yat-sen) University, Guangzhou 510102, P.R. China

Li Yan

Second Affiliated Hospital, Zhongshan (Sun Yat-sen) University, Guangzhou 510102, P.R. China

In this review, some strategies to fabricate starch-based hydrogels are summarized and presented. Hydrophilic hydrogels based on native starch, pure starch components and their derivatives are important due to their swellability in water, biocompatibility and biodegradability. For the preparation of chemically cross-linked starch-based hydrogels, one-step and two-step synthesis by free radical polymerization, cross-linking by chemical reaction of complementary groups and radiation-induced polymerization with the help of gamma or electron beams, are used. For the preparation of physically cross-linked starch-based hydrogels, a novel self-assembly method was used. Some advantages and disadvantages of these synthesis approaches are briefly discussed.

Key Words: starch • hydrogels • drug release • biomedical application

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 3, 297-314 (2005)
DOI: 10.1177/0883911505053382
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[Abstract] [PDF]