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Journal of Bioactive and Compatible Polymers
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Gel Beads Composed of Chitosan and Polyacids and Their Blood Compatibility

D. Paneva

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria manolova{at}polymer.bas.bg

I. Rashkov

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

D. Danchev

Department of Haemostasis, Military Medical Academy, 1606 Sofia, Bulgaria

Chitosan gel beads were prepared as a model for new chitosan materials and their blood compatibility was evaluated in vitroin human pool plasma and in human whole blood. The one-stage method for the preparation of monolithic beads consisted of performing a template polymerization of 2-acryloylamido-2-methylpropanesulfonic acid (AMPS) or copolymerization of AMPS and acrylic acid. Monolithic beads of semi-interpenetrating networks chitosan/copolymer were prepared in the presence of a cross-linking agent. The equilibrium degree of swelling of the beads was dependent on the composition. Reservoir-type beads consisting of a chitosan core and a coating of polyelectrolyte complex with anticoagulant activity and chitosan were also prepared. The reservoir-type beads and the monolithic beads showed improved compatibility with blood in comparison with the uncoated chitosan beads.

Key Words: chitosan • homoand copolymers of AMPS • gel beads • polyelectrolyte complexes • semi-IPN • anticoagulant activity • blood compatibility

Journal of Bioactive and Compatible Polymers, Vol. 20, No. 2, 133-151 (2005)
DOI: 10.1177/0883911505051855
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