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Journal of Bioactive and Compatible Polymers
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Evaluation of Dendritic Gadolinium Complexes as MRI Contrast Agents

Guo-Ping Yan

School of Physical and Chemical Sciences, Queensland University of, Technology, GPO Box 2434, Brisbane, Q4001, Australiaguopyan{at}hotmail.com

Steven E. Bottle

School of Physical and Chemical Sciences, Queensland University of, Technology, GPO Box 2434, Brisbane, Q4001, Australia

Ren-Xi Zhuo

Department of Chemistry, Wuhan University, Wuhan 430072, PR China

Li Wei

Mai-Li Liu

Li-Yun Li

State Key Laboratory of Magnetic Resonance and Atomic and Molecular, Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of, Sciences, Wuhan 430071, PR China

A series of dendritic gadolinium complexes based on dendrimers with 1,4,7,10-tetraazacyclododecane as the core were synthesized. Both diethylenetriaminepentaacetic acid and pyridoxamine were incorporated to the amine groups on the surface to give the dendritic ligands. These dendritic ligands were then reacted with gadolinium chloride to yield the corresponding dendritic gadolinium complexes. The dendritic ligands and their gadolinium complexes were characterized by 1HNMR, IR, UV and elemental analysis. Relaxivity studies showed that the dendritic gadolinium complexes have higher relaxation effectiveness than that of the clinically used small molecular gadolinium complexes. Magnetic resonance imaging of the liver in rats indicated that the dendritic gadolinium complex containing pyridoxamine enhances the image contrast of the liver, provides prolonged intravascular duration and produces highly contrasted visualization of blood vessels in the liver.

Key Words: magnetic resonance imaging (MRI) • gadolinium complex • dendrimer • relaxivity • pyridoxamine

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 6, 453-465 (2004)
DOI: 10.1177/0883911504048375
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