Journal of Bioactive and Compatible Polymers

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, X.
Right arrow Articles by Liang, X.D.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Bioactive and Compatible Polymers, Vol. 19, No. 5, 409-419 (2004)
DOI: 10.1177/0883911504046678
© 2004 SAGE Publications

Anastomosis of Small Arteries Using a Soluble Stent and Bioglue

Xiaohong Wang

Biomanufacture Laboratory, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, P.R.Chinawangxiaohong{at}tsinghua.edu.cn

Yongnan Yan

Renji Zhang

Biomanufacture Laboratory, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, P.R.China

Y.W. Fan

F.Z. Cui

Q.L. Feng

Department of Materials Science & Engineering, Tsinghua University, Beijing, 100084, P.R.China

X.D. Liang

General Hospital of People’s Liberation Army, Beijing, 100854, P.R. China

A soluble intralumenal stent for vascular anastomosis was prepared from glucose, dextran-40 and disodium (1–4)-2-deoxy-2-sulfoamino-ß-D-glucopyranuronan (S-chitosan). The in vitro and in vivo solubility of the stent was tested. Animal tests were carried out using femoral arteries of rabbits. In comparison with the previously reported data for poly(ethylene glycol), (PEG) and sugar stents, the S-chitosan containing stent (S-sugar stent) had a shorter dissolution time and a higher vessel patency rate that led to a higher rabbit survival rate. Neither irritation nor thrombosis, due to the introduction of S-sugar stent, was observed from histological sections 2 months after the anastomosis. This S-chitosan containing sugar stent is a promising candidate for fast sutureless anastomosis of vessels in non-trauma surgery.

Key Words: anastomosis • sutureless • dissolvable stent • S-chitosan • sugar


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?