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Journal of Bioactive and Compatible Polymers
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Dendritic Poly-[N-(2-Hydroxyethyl)-L-Glutamine] as Potential Drug Carrier

Katleen de Winne

Sylvie Vanderkerken

Katty Hoste

Peter Dubruel

Polymer Materials Research Group, Ghent University, Krijgslaan 281 S4-bis, 9000 Ghent, Belgium

Etienne Schacht

Polymer Materials Research Group, Ghent University, Krijgslaan 281 S4-bis, 9000 Ghent, Belgiumetienne.schacht{at}UGent.be

Marketa Jelinkova

Blanka Rihova

Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic

Dendritic poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) with different molecular weights were synthesized by aminolysis of dendritic poly-({gamma}-benzyl-L-glutamate) (PBG), which was obtained by polymerization of the corresponding N-carboxyanhydride (NCA) with poly(amido amine) (PAMAM, starburst®) of the fourth generation as initiator. Dynamic light scattering (DLS) was used to determine the size of the polymeric carriers and to compare the dendritic polymer to the linear analogue. The body distribution and blood clearance of 125 I-radiolabelled linear and dendritic PHEG with similar molecular weight were investigated in female BALB/c mice.

Key Words: polymeric carrier • poly-[N-(2-hydroxyethyl)-L-glutamine] • body distribution • dendrimers • poly(amino amide)

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 5, 367-382 (2004)
DOI: 10.1177/0883911504046680
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