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Journal of Bioactive and Compatible Polymers
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Controlling Biostability of Collagen Films for Fibroblast Cytocompatibility

Zhengwei Mao

Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

Changyou Gao

Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, Chinacygao{at}mail.hz.zj.cn

Dengyong Wang

Lie Ma

Jiacong Shen

Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

The influence of cross-linking reagent, glutaraldehyde, on the biostability of collagen films was examined. With greater cross-linking, water absorption ability, swelling degree and degradation rate were all decreased. Based on scanning electron microscopy observations, the collagen films changed from a compact structure to a fiber-dominated morphology after cross-linking. Cross-linking provides a more integrated fiber-like structure that impeded degradation. To assess the influence of the cross-linking on cytocompatibility, in vitro cell culture was performed on the cross-linked collagen films using human fibroblasts. Good cytocompatibility of the initial collagen was largely retained after cross-linking, while biostability was greatly improved.

Key Words: collagen • cross-link • glutaraldehyde • skin • tissue engineering • cytocompatibility

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 5, 353-365 (2004)
DOI: 10.1177/0883911504046689
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