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Journal of Bioactive and Compatible Polymers
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Natural and Synthetic Hydroxyapatite Filled PCL: Mechanical Properties and Biocompatibility Analysis

Luigi Calandrelli

Istituto di Chimica e Tecnologia dei Polimeri, CNR Via Campi Flegrei, 34 80078 Pozzuoli

Barbara Immirzi

Istituto di Chimica e Tecnologia dei Polimeri, CNR Via Campi Flegrei, 34 80078 Pozzuoli

Mario Malinconico

Istituto di Chimica e Tecnologia dei Polimeri, CNR Via Campi Flegrei, 34 80078 Pozzuoli

Susanne Luessenheide

University of Applied Science Osnabrueck, Osnabrueck, Germany

Irene Passaro

Dipartimento di Biochimica e Biofisica "F. Cedrangolo" Facoltà di Medicina e Chirurgia, Seconda Università di Napoli Via De Crecchio, 7 - 80138 Napoli, Italy

Rachele di Pasquale

Dipartimento di Biochimica e Biofisica "F. Cedrangolo" Facoltà di Medicina e Chirurgia, Seconda Università di Napoli Via De Crecchio, 7 - 80138 Napoli, Italy

Adriana Oliva

Dipartimento di Biochimica e Biofisica "F. Cedrangolo" Facoltà di Medicina e Chirurgia, Seconda Università di Napoli Via De Crecchio, 7 - 80138 Napoli, Italy, adriana.oliva{at}unina2.it

Hydroxyapatite (Ca10(PO4)6(OH)2) is one of the most biocompatible ceramics because it is similar to the mineral constituents of human bone and teeth. Composites of hydroxyapatite (HA) and biodegradable polymers such as polycaprolactone (PCL) are interesting materials for medical applications, especially for bone replacement. With the aim to improve the properties of biodegradable polyester-based devices, we have prepared and characterized novel composites made of polycaprolactone and natural or synthetic hydroxyapatite. The composites were screened for cytocompatibility by a direct contact method, in view of the future application of these hydroxyapatite filled PCL polymers as scaffolds for bone engineering. Primary cultures of human bone marrow mesenchymal stem cells (MSC) were selected as the most appropriate models to study the in vitro performance of these materials.

Key Words: polycaprolactone • hydroxyapatite • whiskers • biocompatibility

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 4, 301-313 (2004)
DOI: 10.1177/0883911504045234
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Huade Li, Qiang Zheng, Yuxiang Xiao, Jie Feng, Zhongli Shi, and Zhijun Pan
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Journal of Bioactive and Compatible Polymers, January 1, 2009; 24(1): 83 - 99.
[Abstract] [PDF]