This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bonina, P. Articles by Naydenov, M. Search for Related Content Social Bookmarking                         What's this?

pH-Sensitive Hydrogels Composed of Chitosan and Polyacrylamide: Enzymatic Degradation

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

T. Petrova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria manolova{at}polymer.bas.bg

I. Rashkov

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

M. Naydenov

Department of Microbiology, Agricultural University, 4000 Plovdiv, Bulgaria

The enzymatic degradation of three types of pH-sensitive hydrogels, composed of the natural polyaminosaccharide chitosan and polyacrylamide, was studied. The weight of the films that were made with net-PAAm- i-chitosan, net-chitosan- i-PAAm and net-chitosan- net-PAAm decreased in the presence of the Trichoderma viride enzyme complex; thus, the chitosan in the composite retained its degradability after crosslinking. The rate of enzymatic degradation depended on the structure of the network, on the amount of crosslinking agents, on the pH of the medium and on the temperature. Crosslinked chitosan alone degraded slower than net-chitosan- i-PAAm; this was attributed to the facilitated penetration of enzyme by the water-soluble PAAm in the semi-IPNs. T. viride embedded in chitosan/PAAm films or beads developed and reproduced normally. However, T. viride embedded in net-chitosani-PAAm developed considerably slower, and development was not detected in the case of net-PAAm- i-chitosan. All of the networks proved to be appropriate carriers of Bacillus subtilis.

Key Words: Chitosan • polyacrylamide • pH-sensitive hydrogels • semi-IPNs • enzymatic degradation • T. viride • B. subtilis.

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 3, 197-208 (2004)
DOI: 10.1177/0883911504044455


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Long Zhao, H. Mitomo, and F. Yosh Synthesis of pH-Sensitive and Biodegradable CM-Cellulose/Chitosan Polyampholytic Hydrogels with Electron Beam Irradiation Journal of Bioactive and Compatible Polymers, July 1, 2008; 23(4): 319 - 333. [Abstract] [PDF]