This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yang, S. Articles by Rocca, J. G. Search for Related Content Social Bookmarking                         What's this?

Semi-interpenetrating Polymer Network Superporous Hydrogels Based on Poly(3-Sulfopropyl Acrylate, Potassium Salt) and Poly(Vinyl Alcohol): Synthesis and Characterization

Purdue University, Department of Pharmaceutics and Biomedical Engineering, West Lafayette, IN 47907, USA

Kinam Park

Purdue University, Department of Pharmaceutics and Biomedical Engineering, West Lafayette, IN 47907, USA kpark{at}purdue.edu

Jose G. Rocca

Kos Pharmaceuticals, Inc., Two Oakwood Boulevard, Suite 100, Hollywood, FL 33020, USA

Semi-interpenetrating polymer network (semi-IPN) superporous hydrogels (SPHs) based on poly(3-sulfopropyl acrylate, potassium salt) (PSPA) and linear polymers were synthesized using poly(ethylene glycol) diacrylate (PEGDA) or N,N'-methylenebisacrylamide (BIS) as a crosslinker. The swelling ratio of SPHs was determined by measuring the weight of absorbed water; and the mechanical strength of swollen SPHs was evaluated using texture analyzer. Taguchi orthogonal experimental design [L9(3⁴)] was used to evaluate the influence of four factors, consisting of the ratios of 3-sulfopropyl acrylate (SPA) to PEGDA, to initiator, and to acrylic acid (AAc), and acidification of PSPASPHs, with each containing three levels on the swelling ratio and mechanical strength of semi-IPN PSPA-SPHs. Analysis of variance (ANOVA) of the experimental design results was carried out using a SAS program. The structure of SPHs was examined using a scanning electron microscope (SEM). Among the polymers evaluated, poly(vinyl alcohol) (PVA) was the best linear polymer to improve the mechanical strength of swollen SPHs. ANOVA indicated that the ratio of SPA to PEGDA and to an initiator, as well as acidification had significant effects on the swelling ratios of PSPA-SPHs. The ratio of SPA to AAc and acidification had significant effects on the mechanical strength, which deceased with increased swelling ratio and time. The optimized semi-IPN PSPA-SPH containing 5% w/w PVA had a swelling ratio 20 times greater within minutes and then up to 40 times. The mechanical strength was over 200 g/cm² for a fully swollen gel in a pH 1.2HCl medium. The optimal PSPA-SPH has swelling and mechanical properties suitable for development of gastro retentive drug delivery systems.

Key Words: superporous hydrogel • semi-interpenetrating polymer network • poly(3-sulfopropyl acrylate, potassium salt) • poly(vinyl alcohol)

Journal of Bioactive and Compatible Polymers, Vol. 19, No. 2, 81-100 (2004)
DOI: 10.1177/0883911504042641


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?