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Journal of Bioactive and Compatible Polymers
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Preparation and Characterization of Collagen/Chitosan Matrices As Potential Biomaterials

X. H. Wang

wangxiaohong{at}tsinghua.edu.cn

F. Z. Cui

cuifz{at}mail.tsinghua.edu.cn

Q. L. Feng

Department of Materials Science & Engineering Tsinghua University Beijing 100084, P.R. China

J. C. Li

Y. H. Zhang

Institute of General Surgery Chinese PLA General Hospital Beijing 100853, P.R. China

Chitosan was covalently coupled to type I collagen by using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide in morpholinoethane sulfonic acid buffer. The physico-chemical characteristics of the collagen/chitosan matrices (CCM) were evaluated by electron spectroscopy and tensile mechanical strength. The platelet deposition and endothelial cell culture experiments showed that the CCM have good cell compatibility and excellent blood compatibility. The results suggest that the CCM creates an appropriate environment for the regeneration of endothelial cells and are promising candidates as biomaterials for the tissue regeneration scaffolds.

Key Words: collagen/chitosan matrices (CCM) • 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide • endothelial cell • lungs

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 6, 453-467 (2003)
DOI: 10.1177/0883911503040434
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