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Journal of Bioactive and Compatible Polymers
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Polysaccharide Scaffolds Prepared by Crosslinking of Polysaccharides with Chitosan or Proteins for Cell Growth

T. Ehrenfreund-Kleinman

A. J. Domb

Department of Medicinal Chemistry and Natural Products School of Pharmacy, Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem 91120, Israeladomb{at}md.huji.ac.il

J. Golenser

Department of Parasitology Hebrew University-Hadassah Medical School 91120 The Hebrew University of Jerusalem Jerusalem, Israel

The synthesis and characterization of sponges composed of polysaccharides crosslinked with different amine-containing natural polymers for the use as cell carriers is described. Sponges based on arabinogalactan, dextran, and amylose were synthesized by crosslinking with chitosan, or with the protein: gelatin, or bovine serum albumin. Highly porous sponges that rapidly absorbed water with little change in size were obtained. The degradation rate of the sponges was varied by controlling the oxidation with periodate or perchlorite for different times and ratios, in order to tailor the sponges for use as cell carriers in tissue engineering. The sponges performed well as a platform for the growth of bEnd2 cells. The chitosan based sponges were the most effective and cell compatible.

Key Words: tissue engineering • polysaccharides • arabinogalactan • crosslinked sponges

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 5, 323-338 (2003)
DOI: 10.1177/0883911503038234
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