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Sodium Alginate as a Scaffold Material for Hepatic Tissue Engineering

Department of Materials Science & Engineering, Tsinghua University, Beijing 100084, P.R. China

X. H. Wang

Department of Materials Science & Engineering, Tsinghua University, Beijing 100084, P.R. China

Q. L. Feng

Department of Materials Science & Engineering, Tsinghua University, Beijing 100084, P.R. China, biomater{at}mail.tsinghua.edu.cn

F. Z. Cui

Department of Materials Science & Engineering, Tsinghua University, Beijing 100084, P.R. China

Y. X. Xu

Institute of General Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China

X. H. Song

Institute of General Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China

Sodium alginate, which has excellent biocompatibility, was evaluated as a scaffold material for hepatic tissue engineering. It is found that hepatocyte cells attached and proliferated well on films made from sodium alginate. Furthermore, the attached hepatocytes had normal functions, such as synthesizing albumin which was detected by immunohistochemical staining for albumin.

Key Words: sodium alginate • hepatic tissue engineering • hepatocyte • albumin • cell attachment • cell proliferation • cytocompatibility

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 4, 249-257 (2003)
DOI: 10.1177/088391103036044


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