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Note: Biological Activity of C6-Oxidized Hyaluronic Acid: Antibacterial Properties of the Zn(II) Salt

Department of Chemistry University `'La Sapienza" Rome, Italy

Andrea Francescangeli

Department of Chemistry University `'La Sapienza" Rome, Italy

Partially oxidized hyaluronan sodium and zinc salts and hyaluronan zinc salts were prepared. The antibacterial activity of hyaluronic acid and of C(6)-oxidized hyaluronic acid zinc salts (HAZn⁺² and HAOXZn⁺²) were evaluated against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli bacterial strains. HAOXZn⁺² showed a higher antibacterial effect than HAZn⁺² with E. coli and S. aureus; however, neither zinc salt was not able to promote any antiseptic activity against P. aeruginosa.

Key Words: hyaluronic acid • regioselective TEMPO-mediated oxidation • hyaluronan zinc salts • antibacterial activity

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 3, 229-235 (2003)
DOI: 10.1177/0883911503035387


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