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Journal of Bioactive and Compatible Polymers
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Polymeric Drug for Antimicrobial Activity Studies: Synthesis and Characterization

A. Arun

Central Leather Research Institute Adyar, Chennai - 600 020, India

B. S. R. Reddy

Central Leather Research Institute Adyar, Chennai - 600 020, India induchem2000{at}yahoo.com

M. Rajkumar

Center for Environmental Studies Anna University Chennai - 600 025, India

In this study, 2',4-dichloro-5'-fluoro-1-ene-2-(4-hydroxyphenyl)phenone (EHP) was synthesized using 4-hydroxybenzaldehyde and 2, 4-dichloro-5-fluoro acetophenone (DFA); 4-[3-(2,4-dichloro-5-fluorophenyl)-3-oxoprop-1-en-1-yl]phenyl acrylate (EAP) was prepared by reacting EHP with acryloyl chloride. Poly(EAP) was prepared by solution polymerization and was characterized by IR, 1H and 13C NMR. The molecular weights of the polymer (EAP) (Mw: 3900 and Mn: 3600) were characterized by gel permeation chromatographic. Thermal stability of the polymer was characterized by thermogravimetric analysis method. Antimicrobial activity of the DFA, EHP, EAP and poly(EAP) were tested on three microorganisms; Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Salmonella typhi ATCC 6539. The minimum concentration of the drug needed to inhibit the growth of the bacteria was estimated using a photometry assay.

Key Words: 2',4-Dichloro-5'-fluoro-1-ene-2-(4-hydroxyphenyl)phenone • free radical • Antimicrobial activity • Escherichia coli • Pseudomonas aeruginosa • Salmonella typhi

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 3, 219-228 (2003)
DOI: 10.1177/0883911503035385
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