Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Domurado, D.
Right arrow Articles by Simonnet, F.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

In Vivo Fates of Degradable Poly(ß-Malic Acid) and of its Precursor, Malic Acid

Dominique Domurado

Centre de Recherche sur les Biopolymères Artificiels UMR 5473 CNRS, INSERM Faculty of Pharmacy 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France

Philippe Fournié

Centre de Recherche sur les Biopolymères Artificiels UMR 5473 CNRS, INSERM Faculty of Pharmacy 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France

Christian Braud

Centre de Recherche sur les Biopolymères Artificiels UMR 5473 CNRS, INSERM Faculty of Pharmacy 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France

Michel Vert

Centre de Recherche sur les Biopolymères Artificiels UMR 5473 CNRS, INSERM Faculty of Pharmacy 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France

Philippe Guérin

LRP UMR C7581 CNRS 2-8 rue Henry Dunant 94320 Thiais, France

Françoise Simonnet

Laboratoire de Radiobiologie Institut National des Sciences et Techniques Nucléaires BP 6, 91190 Gif-sur-Yvette, France

To determine whether degradation could influence the in vivo elimination pattern of poly(ß-malic acid) in mice, radioactive urinary excretion and 14CO2 expiration were studied after intravenous injection of 14C-radiolabeled poly(ß-malic acid) and of its precursor, 14C-malate. The precursor administration led to rapid 14CO2 exhalation, and only negligible urinary elimination. The reverse was observed for the polymer. It was concluded that: (i) the in vivo degradation of poly(ß-malic acid) chains, if any during the 24-h period of the study, did not release detectable malate molecules, (ii) the large urinary excretion of poly(ß-malic acid) was due to the molar masses being less than the renal filtration threshold, (iii) the degradation of the poly(ß-malic acid) chains in blood was slow enough to allow the fraction with higher molar masses to enter the interstitial space of the tissues, and possibly cells.

Key Words: biodegradable polymer • in vivo fate • pharmacokinetics • radioactive follow-up • 14CO2 expiration • urinary excretion

Journal of Bioactive and Compatible Polymers, Vol. 18, No. 1, 23-32 (2003)
DOI: 10.1177/0883911503018001003
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?