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Journal of Bioactive and Compatible Polymers
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Morpho-Structural Investigations of Biomaterials for Biocidal Activity

A. Pugnaloni

F. Gabbanelli

Istituto di Morfologia Umana Normale, Universitä di Ancona, Via Tronto 10/A, 60020 Ancona, Italy

M. Mattioli-Belmonte

Istituto di Morfologia Umana Normale, Universitä di Ancona, Via Tronto 10/A, 60020 Ancona, Italybelmonte{at}med.unian.it

A. Delfino

G. Biagini

Istituto di Morfologia Umana Normale, Universitä di Ancona, Via Tronto 10/A, 60020 Ancona, Italy

M. G. Tucci

G. Ricotti

U.O Dermatologia, I.N.R.C.A, Via della Montagnola, 60100 Ancona, Italy

F. Orlando

C. Viticchi

Centro Servizi e Biotecnologie I.N.R.C.A, Via Birarelli, 60100 Ancona, Italy

M. Fini

Chirurgia Sperimentale Istituti di Ricerca "Rizzoli", Via Di Barbiano 1/10 Bologna, Italy

A new wound dressing made of gelatin and Ag, was evaluated for the management of tissue reconstitution in rats. The gelatin–based dressing, with metabolic stimulation properties that favored the recovery of the skin was made of stiff sheets to supply the repairingtissue with mechanical support. The gelatin sheets enhanced the development of collagen fibers and subsequently cell proliferation at the level of stromal and vascular elements. A protocol based on the utilization of natural biomaterials in the presence of low concentrations of a biocidal was proposed which could control microbiocidal activities principally in burned and debilitated patients.

Key Words: biomaterials • cutaneous repair • wound dressing • gelatin • collagen • biocides

Journal of Bioactive and Compatible Polymers, Vol. 17, No. 6, 451-462 (2002)
DOI: 10.1177/088391102031641
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