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Journal of Bioactive and Compatible Polymers
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Synthesis and Antimutagenic Properties of Novel Systems Based on Poly(Quaternized Ammonium) Salts

V. A. Alexandrova

Topchiev Institute of Petrochemical Synthesis, RAS Leninsky pr.29, Moscow, 117912 RussiaTimofeeva{at}ips.ac.ru

G. V. Obukhova

D. A. Topchiev

Topchiev Institute of Petrochemical Synthesis, RAS Leninsky pr.29, Moscow, 117912 Russia

The adsorptive capacity on the model bilayer lipid membrane and antimutagenic activity of synthetic polycations of diallyldimethylammonium chloride (DADMACh) were studied. A correlation between the total positive charge of a macro-ion and the polymer efficiency as a bioprotector was found. A number of ternary copolymers (TCP) containing different amounts of di(tertbutyl)phenol (TBPh) in the side chain of a DADMACh and acrylic acid binary copolymer (30:70 mol%) were prepared. A correlation between the amount of the TBPh in the TCP(TBPh) structure and both the antiradical and the antimutagenic efficiencies was obtained. Taking into account the correlations found in model synthetic polycations, modification of chitosan was fulfilled. Chitosan derivatives containing quaternary ammonium groups and TBPh in the polymer side chain improved the antimutagenic efficiency of the polymer in a plant test-system from 48 to 93%.

Key Words: antimutagenic • chitin • chitosan • polycation • antiradical • radiation protection

Journal of Bioactive and Compatible Polymers, Vol. 17, No. 5, 321-341 (2002)
DOI: 10.1177/0883911502017005556
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