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Preparation of Surface-Engineered Elastin/Lamin Nerve Guide Tubes of Poly(Lactic Acid)/Poly(Ethylene Vinyl Acetate)

Department of Cardiology Mayo Mail Code:508, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USAchand025{at}tc.umn.edu

Gundu H.R. Rao

Department of Lab Medicine and Pathology, Mayo Mail Code:508, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA

In this study, a spray coating technique was used to prepare poly(lactic acid) (PLA) tubes. To improve the flexibility of these devices, an elastomeric polymer, poly(ethylene vinyl acetate) (PEVAc), was added to the PLA. The PLA/PEVAc tubes were further surface modified with elastin and laminin via carbodiimide and glutaraldehyde treatment. This study evaluated the surface graft matrix components (elastin and laminin) on PLA/PEVAc tubes as a method for regenerating biointeractive materials for nerve growth and tissue engineering.

Journal of Bioactive and Compatible Polymers, Vol. 17, No. 3, 183-194 (2002)
DOI: 10.1106/088391102026102


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