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Separation of Chitosan from Penicillium Chrysogenum Mycelium and its Applications

Wang Binwu

Shi Xinyuan

Department of Biochemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China

A process to separate chitosan from Penicillium chrysogenum mycelium was developed. Alkaline treatment and acetic acid extraction were used for deacetylating chitin to chitosan. The molecular weight of the chitosan was 3.6 x 10⁴ and the degree of deacetylation was 84%. Analysis indicated that the chitosan from Penicillium chrysogenum mycelium was similar to that obtained from shrimp. The chitosan from the mycelium was used to prepare microcapsules for controlled drug release. The chitosan microcapsules reached maximum release of vitamin D₂ after 10 h which avoided the problem of instability in gastric juice; the chitosan microcapsules are suitable for adsorption of vitamin D₂ in intestines.

Journal of Bioactive and Compatible Polymers, Vol. 17, No. 3, 173-182 (2002)
DOI: 10.1106/088391102026103


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