This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bariyanga, J. Search for Related Content Social Bookmarking                   What's this?

Synthesis, Characterization and Biodegradability of Poly(Ethylene Glycol)-Bound Molecule Platinum Complexcontaining Ferrocenyl Moiety Using MALDI Time-of-Flight Mass Spectrometry

School of Chemical Sciences, University of the North (Qwa-Qwa), Private Bag X13, 9866 Puthaditjhaba, South Africa, Department of Chemistry, University of Wisconsin-Milwaukee, 3210 N, Cramer St. Milwaukee, WI 53211-3029.baryanga{at}uwm.edu

Monomethoxypolyethylene glycol (MPEG) was bound to a ferroceny/ketimine and the resulting molecule complexed with platinum ion. The chief means of characterization of the intermediate and final compounds was Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) mass spectrometry. The results indicated some degree of decomposition by the MALDI source for the intermediate compounds and the presence of platinum complex as a chelate. The biodegradability of the MPEG-bound molecule complex was also studied using papain at 37°C and pH 7.80 in ammonium phosphate buffer to avoid metal catonization during mass ionization. The mass spectra showed that the complex was 50% degraded within 20 min and then remained unchanged up to 48 hours.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?