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Journal of Bioactive and Compatible Polymers
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Mobility of Poly(Ethylene Oxide) Segments on Surface of Lecithin Liposomes

Nobuhiro Morone

Yukihisa Okumura

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Kyoto 606-8501, Japan

Junzo Sunamoto

Niihama National College of Technology, Yagumo-cho 7-1, Niihama, Ehime 792-8580, Japan.sunamoto{at}niihama-nct.ac.jp

To better understand the dynamics of PEO-lipid-modified phosphatidylcholine liposomes ("fusogenic liposomes"), the mobility of the PEO segment on the liposomal surface and the fluidity of the bilayer were investigated by measuring the spin-lattice relaxation time (T1by 13C-NMR spectroscopy and by fluorescence depolarization. 13C-NMR studies revealed that the PEO-lipids in this work exhibit similar behavior on liposomal surfaces irrespective of the PEO chain length. Furthermore, with regard to the relationship between morphology and dynamics of the PEO-lipid and phosphatidylcholine mixture, it was found that the mobility of PEO segments are altered by the morphology; liposome < aqueous micelle < monomeric dispersion in organic solution. Fluorescence depolarization studies revealed that liposomal membranes were tighter with the addition of PEO-lipid(12,a31) than with the addition of PEO-lipid(12,a13). In contrast, the reconstitution of PEO-lipid(12,a5) into liposomes increased membrane fluidity.

Key Words: PEO segments • liposomes • fusogenic • mobility • micelles • PEO-lipids

Journal of Bioactive and Compatible Polymers, Vol. 16, No. 3, 194-205 (2001)
DOI: 10.1106/2H6H-P35H-E8DE-DFPD
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[Abstract] [PDF]