Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Morone, N.
Right arrow Articles by Sunamoto, J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Modification of Phosphatidylcholine Liposomes with Poly(ethylene oxide)-Substituted Lipids

Nobuhiro Morone

Masahiro Yamauchi

Yukihisa Okumura

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Kyoto 606-8501, Japan

Junzo Sunamoto

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Kyoto 606-8501, Japan; Niihama National College of Technology, Yagumo-cho 7-1, Niihama, Ehime 792-8580, Japan.sunamoto{at}niihama-nct.ac.jp

Modification of egg phosphatidylcholine (eggPC) and dimyristoylphosphatidylcholine liposomes with poly(ethylene oxide)-substituted lipids [PEO-lipid(m,n); m and n mean, respectively, the chain length of alkyl group and the number of PEO segments]. Morphologies of these supermolecules were investigated by means of laser dynamic light scattering and transmission electron microscopy. Reconstitution of the PEO-lipid to eggPC liposome was possible below 40–50 mol% of total lipids for PEO-lipid(12,5), and 30–40 mol% for PEO-lipid(12,13) and PEO-lipid(12,31). Effective encapsulation of FITC-dextran (1.96 kDa) into the liposome was obtained using the eggPC liposome modified with PEO-lipid. This PEO-modified liposome showed sufficient barrier function to water-soluble polymers such as dextran. Through various studies, it was found that PEO-lipid(12,13) is relatively compatible for modifying conventional eggPC liposome.

Journal of Bioactive and Compatible Polymers, Vol. 16, No. 3, 167-193 (2001)
DOI: 10.1106/T71R-HGPE-572V-LH61
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Journal of Bioactive and Compatible PolymersHome page
N. Morone, T. Ueda, Y. Tsudo, Y. Okumura, V. Rosilio, A. Baszkin, and J. Sunamoto
Surface Pressure Analysis of Poly(ethylene oxide)-Modified Fusogenic Liposomes Incorporated into a Phospholipid Monolayer
Journal of Bioactive and Compatible Polymers, January 1, 2007; 22(1): 5 - 18.
[Abstract] [PDF]

Home page
 Journal of Bioactive and Compatible PolymersHome page
M. Haratake and J. Sunamoto
Direct Fusion between Poly(ethylene oxide)-lipid Modified Liposomes and Murine Mitotic B16 Melanoma Cells
Journal of Bioactive and Compatible Polymers, November 1, 2006; 21(6): 503 - 517.
[Abstract] [PDF]