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Journal of Bioactive and Compatible Polymers, Vol. 16, No. 2, 145-157 (2001)
DOI: 10.1106/NYTK-W829-UWC1-PMLW

Chitosan and Gelatin as Engineered Dressing for Wound Repair

M. G. Tucci

G. Ricotti

U.O Dermatologia, I.N.R.C.A., Via della Montagnola, 60100 Ancona, Italy

M. Mattioli-Belmonte

CIBAD—Centro Biomateriali Innovativi, Istituto di Morfologia Umana Normale, Università di Ancona, Via Tronto 10/A, 60020 Ancona, Italybelmonte{at}popcsi.unian.it

F. Gabbanelli

G. Lucarini

CIBAD—Centro Biomateriali Innovativi, Istituto di Morfologia Umana Normale, Università di Ancona, Via Tronto 10/A, 60020 Ancona, Italy

F. Orlando

C. Viticchi

Centro Servizi e Biotecnologie I.N.R.C.A., Via Birarelli, 60100 Ancona, Italy

A. Bigi

S. Panzavolta

N. Roveri

Dipartimento di Chimica Ciamician, Università di Bologna, Via Selmi 2, 40100 Bologna, Italy

G. Morganti

MAVI SUD S.r.l., Via dell’Industria, Aprilia (LT), Italy

R. A. A. Muzzarelli

CIBAD—Centro Biomateriali Innovativi, Università di Ancona, Via Ranieri 67, 60100 Ancona Italy

A therapeutic support for the less effective steps in skin’s recovery should improve reparative capacity. A morphological and immunohistochemical evaluation of tissue repair in rats in the presence of chitosan glycolate gel and cross-linked gelatin wound dressings was conducted and compared. In chitosan-treated animals, the repaired dermis preserved high cellularity with mesenchymal features associated with a rich vascular network. These aspects were less marked in the presence of Phytostimuline gauze or gelatin. The hydrophilic properties of chitosan are clearly demonstrated by the high level of hydration observed in the neoformed tissue. The chitosan gel was able to modulate the early steps of wound healing. Cross-linked gelatin represents an active dressing for the more dystrophic wounded tissues often associated with aging and systemic disease.


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