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Journal of Bioactive and Compatible Polymers
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Interaction of Cultured Chondrocytes with Chitosan Scaffold

Alpaslan Senköü

Aykin Simsek

Gazi University, School of Medicine, Department of Orthopaedics and Traumatology, 06500 Besevler, Ankara, Turkey

Feride I. Sahin

Sevda Menevse

Gazi University, School of Medicine, Department of Medical Biology and Genetics, 06500 Besevler, Ankara, Turkey

Canan Özogul

Gazi University, School of Medicine, Department of Histology and Embryology, 06500 Besevler, Ankara, Turkey

Emir Baki Denkbas

Hacettepe University, Department of Chemistry, Biochemistry Division, TUBITAK-Center of Excellence: POLBITEK, 06532 Beytepe, Ankara, Turkey

Erhan Piskin

Hacettepe University, Chemical Engineering Department and Bioengineering Division, TUBITAK-Center of Excellence: POLBITEK, 06532 Beytepe, Ankara, Turkey

Chitosan scaffolds with sponge-like structures were prepared by a wet spinning technique. Glutaraldehyde was used to control the swellability (water uptake) of the scaffolds. It was possible to reach a swelling ratio about 56.8% in aqueous medium. These wet scaffolds were soft and easily shaped by hand. The cartilage specimen was obtained from the knee joints of a New Zealand white rabbit. Chondrocyte cells were isolated and cultured in vitro for about 10 days to reach a usable population. The cells were then incubated with the chitosan scaffolds and interactions were examined by microscopy. Chondrocyte cells showed junctional complexes consisting of plaques and filaments at the interface. Cell membranes were strongly attached on the chitosan surface.

Journal of Bioactive and Compatible Polymers, Vol. 16, No. 2, 136-144 (2001)
DOI: 10.1106/3EH5-2R73-RC4V-Y9L7
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