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Journal of Bioactive and Compatible Polymers
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Chitosan Beads as Carriers of 8-Hydroxy-7-Iodoquinoline-5-Sulfonic Acid—Loading, Coating by Interpolymer Complex Formation and Drug Release

N. Koseva

O. Stoilova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgariamanolova{at}polymer.bas.bg

I. Rashkov

Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

P.-J. Madec

Laboratoire de Chimie Moléculaire et Thio-organique, Université de Caen, UMR CNRS 6507 ISMRA, 14050 Caen, France

A drug release system based on chitosan and 8-hydroxy-7-iodoquinoline-5-sulfonic acid (SQ), a substance with antimicrobial and antimycotic activity, was developed. Drug loading and release from beads non-crosslinked or crosslinked with glutaraldehyde (GA) and epichlorohydrin (ECC), as well as beads coated with a polyelectrolyte of complex chitosanpoly(2-acryloylamido-2-propane sulfonic acid) under different conditions were compared. SQ was sorbed almost stoichiometrically with respect to the free amino groups in non-crosslinked or crosslinked ECC beads, whereas much higher amounts of SQ were entrapped in the beads crosslinked with GA. The amount of SQ released depended on chitosan crosslinking and pH of the medium, while the release rate of the drug is additionally influenced by drying and coating the beads with a polyelectrolyte complex. The longest period of diffusionally controlled release was observed from dry beads crosslinked with GA at pH 7.

Journal of Bioactive and Compatible Polymers, Vol. 16, No. 1, 3-19 (2001)
DOI: 10.1106/YBKG-B4WC-QMEY-RY85
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