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An Ophthalmic Formulation of a Beta-Adrenoceptor Antagonist, Levobetaxolol, Using Poly(Acrylic Acid) Nanoparticles as Carrier: Loading and Release Studies

Allan S. Hoffman

Department of Bioengineering, Box 352255, University of Washington, Seattle, WA 98195

Poly(acrylic acid) (PAA) nanoparticles were synthesized by reverse microemulsion polymerization using an oil-soluble initiator. The particles had a narrow size range, 50 nm, and were stable in phosphate buffer. The particles were recovered and lyophilized in dry powder form and were redispersible in buffer. The drug levobetaxolol was loaded into the nanoparticles from aqueous drug solutions. When the drug-loaded particles were dispersed in a phosphate buffer solution the drug was released over several hours. The drug formulation in PAA nanoparticles was stable for more than 2 months at 4°C and at room temperature.

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