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Journal of Bioactive and Compatible Polymers
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Macromolecular-Drug Conjugates—Nalidixic Acid and Oxacillin-Dextran

Doina Mihai

"Petru Poni" Institute of Macromolecular Chemistry, 6600 Iassy, Romania

Georgeta Mocanu

"Petru Poni" Institute of Macromolecular Chemistry, 6600 Iassy, Romania

Adrian Carpov

"Petru Poni" Institute of Macromolecular Chemistry, 6600 Iassy, Romania

Dextran conjugates with nalidixic acid and oxacillin, were prepared in two ways: (a) by the reaction of the drugs with chloroacetylated crosslinked dextran microparticles and (b) by the reaction of the drugs with crosslinked polysaccharide microparticles in the presence of a coupling agent. The in vitro behavior of these conjugates was studied and the mechanism of drug release was determined.

Journal of Bioactive and Compatible Polymers, Vol. 15, No. 3, 245-256 (2000)
DOI: 10.1177/088391150001500304
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