This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Edlund, U. Articles by Albertsson, A. C. Search for Related Content Social Bookmarking                         What's this?

Microspheres from Poly(D,L-Lactide)/Poly(1,5-Dioxepan-2-One) Miscible Blends for Controlled Drug Delivery

Dept. of Polymer Technology, Royal Institute of Technology, S-100 44 Stockholm, Sweden

A. C. Albertsson

Dept. of Polymer Technology, Royal Institute of Technology, S-100 44 Stockholm, Sweden

Novel biodegradable microspheres were designed from blends of poly(D,L-lactide) (PDLLA) and poly(1,5-dioxepan-2-one) (PDXO). The addition of PDXO to PDLLA yielded a more pliable and versatile matrix, where the properties can be controlled by means of composition. The components were fully miscible and formed homogeneous, amorphous, smooth and dense microspheres. Blend composition was a vital factor in determining the blend properties, morphology and in vitro degradation. Diclofenac sodium, a non-steroidal anti-inflammatory drug, was incorporated into PDLLA-PDXO microspheres of various composition ratios. Sustained release of drug was obtained. The degradation and release rates of PDLLA-PDXO microspheres were dependent on the blend composition, providing a powerful means of controlling drug delivery.

Journal of Bioactive and Compatible Polymers, Vol. 15, No. 3, 214-229 (2000)
DOI: 10.1177/088391150001500302


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?