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Journal of Bioactive and Compatible Polymers
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Cell Specificity of Macromolecular Assembly of Cholesteryl and Galactoside Groups-Conjugated Pullulan

Ikuo Taniguchi

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Yoshida-Hommachi, Kyoto 606-8501, Japan

Kazunari Akiyoshi

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Yoshida-Hommachi, Kyoto 606-8501, Japan

Junzo Sunamoto

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Yoshida-Hommachi, Kyoto 606-8501, Japan

Yasuo Suda

Department of Chemistry, Faculty of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan

Masayuki Yamamoto

2nd Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan

Galactose or lactose groups were conjugated to cholesterol-bearing pullulan (CHP). The CHP derivatives obtained formed monodisperse nanoparticles upon self-aggregation in water. Nanoparticles of galactoside-conjugated CHP self-aggregates were specifically internalized by rat hepatocytes and HepG2 cells. Galactoside-bearing CHP-coated liposome or oil droplet of O/W-emulsion was also taken up by HepG2 cells. Tissue distribution of the nanoparticle CHP self-aggregates changed dramatically with chemical conjugation of the galactose moiety. Galactoside-bearing nanoparticles were specifically accumulated in the liver.

Journal of Bioactive and Compatible Polymers, Vol. 14, No. 3, 195-212 (1999)
DOI: 10.1177/088391159901400301
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