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Journal of Bioactive and Compatible Polymers
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Thermal and Spectroscopic Characterization of Interactions between 2-Nonyl-1,3-Dioxolane and Stratum Corneum Components

Fabrizio Morganti

Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

Emilia Bramanti

Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

Roberto Solaro

Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

Enzo Benedetti

Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

Emo Chiellini

Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

Enrico Nannipieri

Department of Pharmaceutical Sciences, via Bonanno Pisano 33, 56126 Pisa, Italy

Piero Narducci

Department of Chemical Engineering, via Diotisalvi 2, 56126 Pisa, Italy

Scott F. Krauser

MacroChem Corp., Lexington, MA, USA

Carlos M. Samour

MacroChem Corp., Lexington, MA, USA

The effect of 2-nonyl-1,3-dioxolane (SEPATM) on the structure of human stratum corneum was investigated by FT-IR spectroscopy at variable temperature, differential scanning calorimetry and scanning electron microscopy. A significant influence of SEPATM treatment on position and intensity of IR absorption bands and DSC thermal transitions of SC lipids was detected. An appreciable loosening of SC cell packing was also observed by SEM analysis. These modifications are reversed after SEPATM is removed from the site of application. The results clearly demonstrate that SEPATM is able to modify the structure of the lipid matrix in which corneocytes are embedded, thus suggesting a possible use of SEPATM to increase the permeability of the stratum corneum to lipophilic drugs.

Journal of Bioactive and Compatible Polymers, Vol. 14, No. 2, 162-177 (1999)
DOI: 10.1177/088391159901400205
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