Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Cruz, M. L.
Right arrow Articles by Gil, M. H.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Antituberculosis Macromolecular Prodrugs: Part 1: Isoniazid Conjugates with Poly(Ethylene Glycol) Derivatives

M. L. Cruz

Department of Pharmacy, Faculty of Medical Sciences, PUCCAMI? 13059-740, Campinas, SP, Brazil

M. H. Gil

Department of Chemical Engineering, FCTUC, University of Coimbra, 3000 Coimbra, Portugal

The synthesis, elemental and spectrometric analysis of isoniazid conjugates with polyethylene glycol) (PEG) were obtained. In the first part of the work, acyl isoniazid, hydroxymethyl isoniazid, and modified poly(ethylene glycol) were synthesized. These compounds were characterized by FTIR, by elemental analysis, and by NMR. To obtain antituberculosis macromolecular prodrugs with sustained delivery, the modified PEG were used as carriers by linking, via end group, either isoniazid or its hydroxymethyl derivative.

Journal of Bioactive and Compatible Polymers, Vol. 13, No. 2, 146-157 (1998)
DOI: 10.1177/088391159801300206
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?