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Journal of Bioactive and Compatible Polymers, Vol. 13, No. 2, 102-113 (1998)
DOI: 10.1177/088391159801300202
© 1998 SAGE Publications

Evaluation of Some Microenvironmental Inflences on the Regenerative Mechanisms of the Periodontium: An in Vitro Study

M. Mattioli Belmonte

Institute of Normal Human Morphology, University of Ancona, Via Tronto 10/A, 60020 Torrette (AN), Italy

S. Amati

Institute of Normal Human Morphology, University of Ancona, Via Tronto 10/A, 60020 Torrette (AN), Italy

M. Tesei

Institute of Normal Human Morphology, University of Ancona, Via Tronto 10/A, 60020 Torrette (AN), Italy

G. Biagini

Institute of Normal Human Morphology, University of Ancona, Via Tronto 10/A, 60020 Torrette (AN), Italy

R. Solmi

Institute of Histology, University of Bologna, Via Belmeloro 8, 40125 Bologna, Italy

O. Talassi

Institute of Histology, University of Bologna, Via Belmeloro 8, 40125 Bologna, Italy

L. De Florio

School of Dentistry, University of Ancona, "Villa Maria", 60100 Ancona, Italy

Raa. Muzzarelli

Institute of Biochemistry, University of Ancona, Via Ranieri 67, 60131 Ancona, Italy

Studies have demonstrated the chemotactic response of periodontal ligament cells to a wide range of matrix molecules and growth factors, suggesting a therapeutic role for the latter in tissue lesion restoration. Impaired human gingival and periodontal ligament fibroblasts from adult donors were stimulated in vitro with growth factors or grown on a biosynthetic tissue-guiding membrane in the presence of tetracycline (minocycline) to assess the effects of these molecules on cell proliferation and tolerance to the drug. The results suggest that techniques involving tissue-guiding membranes and growth factors associated with inhibitors of collagenases constitute a promising biological-like way of restoring the delicate equilibrium disrupted by periodontal disease.


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