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Journal of Bioactive and Compatible Polymers
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Biodegradable Poly[(Amino Acid Ester)phosphazenes] for Biomedical Applications

Yahia Lemmouchi

Polymer Materials Research Group, Institute for Biomedical Technologies, IBITECH, University of Gent, Krijgslaan 281 B-9000 Gent, Belgium

Etienne Schacht

Polymer Materials Research Group, Institute for Biomedical Technologies, IBITECH, University of Gent, Krijgslaan 281 B-9000 Gent, Belgium

Stéphane Dejardin

Polymer Materials Research Group, Institute for Biomedical Technologies, IBITECH, University of Gent, Krijgslaan 281 B-9000 Gent, Belgium

Polyphosphazene derivatives with amino acid ester side groups were prepared by reacting poly(dichlorophosphazene) with ethyl esters of amino acids and were characterized by 1H, 31P-NMR and DSC analyses. The in vitro rate of degradation of these polymers depended on the nature of the amino acids while introducing small amounts of depsipeptide ester co-substituents increased degradation rates. The rate of hydrolytic degradation of the poly[(organo)phosphazene] materials could be controlled by the amino acid ester by the depsipeptide ester side group content and by blending poly[(amino acid ester)phosphazenes] with poly[(amino acid ester)-co-(depsipeptide ester)phosphazenes]. Poly[(glycine ethyl ester)phosphazenes] prepared from poly[(dichloro)phosphazenes] degradation rates were independent of molecular weight. Degradations of polymer blends indicate that an intramolecular catalysis ofthe polymer by the pendent carboxylic acid.

Journal of Bioactive and Compatible Polymers, Vol. 13, No. 1, 4-18 (1998)
DOI: 10.1177/088391159801300102
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