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Osteoinduction by Chitosan-Complexed BMP: Morpho-Structural Responses in an Osteoporotic Model

Center for Innovative Biomaterials, Faculty of Medicine, University of Ancona, IT-60131 Ancona, Italy

G. Biagini

Center for Innovative Biomaterials, Faculty of Medicine, University of Ancona, IT-60131 Ancona, Italy

M. Mattioli Belmonte

Center for Innovative Biomaterials, Faculty of Medicine, University of Ancona, IT-60131 Ancona, Italy

O. Talassi

Institute of Histology and Embryology, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy

M. G. Gandolfi

Institute of Histology and Embryology, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy

R. Solmi

Institute of Histology and Embryology, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy

S. Carraro

Institute of Histology and Embryology, University of Bologna, Via Belmeloro 8, 40126 Bologna, Italy

R. Giardino

Experimental Surgery I.O.R., Via di Barbiano 1/10, Bologna, Italy

M. Fini

Experimental Surgery I.O.R., Via di Barbiano 1/10, Bologna, Italy

N. Nicoli-Aldini

Experimental Surgery I.O.R., Via di Barbiano 1/10, Bologna, Italy

Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.

Journal of Bioactive and Compatible Polymers, Vol. 12, No. 4, 321-329 (1997)
DOI: 10.1177/088391159701200405


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