Journal of Bioactive and Compatible Polymers

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shanthi, C.
Right arrow Articles by Rao, K. P.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Bioactive and Compatible Polymers, Vol. 12, No. 4, 308-320 (1997)
DOI: 10.1177/088391159701200404

Regulation of Biocalcification of Bovine Pericardial Tissue b Grafting Poly(Glycidyl Methacrylate-Butylacrylate) Copolymers

C. Shanthi

Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras-600 020, India

K. Panduranga Rao

Biomaterials Laboratory, Central Leather Research Institute, Adyar, Madras-600 020, India

Calcification is the principal cause of failure of glutaraldehyde cross-linked bovine pericardium used as cardiac valve substitutes. Young age, glutaraldehyde pretreatment, and mechanical factors are identified as the main causes of biocalcification. Glutaraldehyde pretreatment is believed to create void spaces in the fiber matrix increasing the availability of physical niches for calcification. In the present paper, glutaraldehyde cross-linked pericardial tissue (GCPC) was filled by grafting polymers with different properties which impart flexibility to the pericardium. These polymers included glycidyl methacrylate (GMA) and butylacrylate (BA) initiated by ceric ion technique. Tensile strength, shrinkage temperature, and differential scanning thermogram were recorded for the glutaraldehyde cross-linked tissues before and after polymer grafting. Calcification studies were done subdermally in rat models. The best anticalcification properties were observed in tissues grafted with GMA: BA monomers of mole ratio of 15:7.2 and initiator concentration of 7.5 x 10-3 mol L-1.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?