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Controlled Release of FITC-BSA from Polymer Coated Gelatin Microspheres

Biomaterials Division, Central Leather Research Institute, Adyar, Madras-600 020, India

K. Panduranga Rao

Biomaterials Division, Central Leather Research Institute, Adyar, Madras-600 020, India

Gelatin microspheres containing the model protein, FITC-BSA, were prepared using the polymer dispersion technique. These microspheres were characterized for their thermal stability using differential scanning calorimetry. In order to prolong the release of the entrapped FITC-BSA, the microspheres were coated with a synthetic and biodegradable polymer, polycaprolactone. The polymer coated microspheres were characterised using infrared spectroscopy and scanning electron microscopy. In vitro release studies indicated that the release rate of FITC-BSA decreased with the increase in the coating concentration of the polymer.

Journal of Bioactive and Compatible Polymers, Vol. 12, No. 2, 127-139 (1997)
DOI: 10.1177/088391159701200204


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