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Journal of Bioactive and Compatible Polymers
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Notes

Nonradioisotope Assay to Examine Adaptability of Nonnatural Amino Acids to the Active Center of Ribosomal a Site

Yoshihiro Ito

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

Naozumi Teramoto

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

Tetsuya Kawai

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

Yukio Imanishi

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

Mitsuyoshi Ueda

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

Atsuo Tanaka

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, 606-01, Japan

A puromycin analog was synthesized and used for assessing the adaptability of the nonnatural amino acid to the active center of reticulocytic ribosome by competitive protein synthesis inhibition using a nonradioisotope procedure. Adaptability of benzyl L-glutamate was assessed by the amino acid-coupled puromycin analog. The puromycin analog inhibited in vitro protein synthesis by the ribosome indicating that chemical modification of side groups by benzyl group did not significantly affect the adaptability of amino acids.

Journal of Bioactive and Compatible Polymers, Vol. 12, No. 1, 59-64 (1997)
DOI: 10.1177/088391159701200105
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