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Synthesis, Characterization, and in Vitro Biodegradation of Poly(Ethylene Glycol) Modified Poly[5N-(2-Hydroxyethyl-L-Glutamine]

Department of Organic Chemistry, Biomaterial and Polymer Research Group, University of Gent, Krijgslaan 281 S4-bis, 9000 Gent, Belgium

Karry Hoste

Department of Organic Chemistry, Biomaterial and Polymer Research Group, University of Gent, Krijgslaan 281 S4-bis, 9000 Gent, Belgium

Dorine Bruneel

Department of Organic Chemistry, Biomaterial and Polymer Research Group, University of Gent, Krijgslaan 281 S4-bis, 9000 Gent, Belgium

Etienne Schacht

Department of Organic Chemistry, Biomaterial and Polymer Research Group, University of Gent, Krijgslaan 281 S4-bis, 9000 Gent, Belgium

Frans De Schryver

Department of Chemistry, Laboratory for Molecular Dynamics and Spectroscopy, Catholic University of Leuven, Celestiynenlaan 200F, 3001 Heverlee, Belgium

The synthesis and in vitro biodegradation of poly(ethylene glycol) modified poly[N-2-hydroxyethyl)L-glutamine] are described. Poly(ethylene glycol) (PEG) with terminal amino endgroup was coupled onto 4-nitrophenyl chloroformate activated poly[N-2-hydroxyethyl-L-glutamineI (PHEG). The influence of the degree of substitution and the molecular weight of PEG side groups on the degradability of the PHEG backbone exposed to isolated rat liver lysosomal enzymes was determined. These data indicate that substitution of PHEG with PEG side-chains only slightly alters the degradability of the carrier. The PEG-grafted polymers showed potential tensioactive properties. DSC analysis demonstrated phase separation of the PEG side-groups in solid state.

Journal of Bioactive and Compatible Polymers, Vol. 11, No. 2, 85-99 (1996)
DOI: 10.1177/088391159601100201


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