Journal of Bioactive and Compatible Polymers

 

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Journal of Bioactive and Compatible Polymers, Vol. 11, No. 2, 122-134 (1996)
DOI: 10.1177/088391159601100204

PEG Modified Anticancer Drugs: Synthesis and Biological Activity

Annapurna Pendri

Enzon Inc., Piscataway, NJ 08854

Carl W. Gilbert

Enzon Inc., Piscataway, NJ 08854

Soundara Soundararajan

Enzon Inc., Piscataway, NJ 08854

Durgadas Bolikal

Enzon Inc., Piscataway, NJ 08854

Robert G. L. Shorr

Enzon Inc., Piscataway, NJ 08854

Richard B. Greenwald

Enzon Inc., Piscataway, NJ 08854

Three well known anticancer drugs, doxorubicin, methotrexate and paclitaxel (taxol), have been modified by the permanent attachment of poly(ethylene glycol)(PEG) and evaluated for in vitro cytotoxic activity against murine leukemias P388 and L1210. The relative potencies of the PEG derivatives suggest that modification of antitumor agents with this type of polymer yields compounds that are highly water soluble but less cytotoxic.


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