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Controlled Release of 17ß-Estradiol from d,l-Lactide/-Caprolactone Copolymers

Department of Pathophysiology, Silesian University, School of Medicine, 41-800, Zabrze, Poland

Mariusz Nowak

Department of Pathophysiology, Silesian University, School of Medicine, 41-800, Zabrze, Poland

Maciej Bero

Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

Piotr Dobrzyiiski

Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

Janusz Kasperczyk

Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800, Zabrze, Poland

A study of the release of ß-estradiol from d,l-lactide/-caprolactone copolymers was performed. The copolymers were used in the form of films (in vitro) and microspheres (in vivo). The dl-lactide content was varied from 50 to 94% in the copolymers studied. It was found that an almost constant rate of ß-estradiol release for about 70 days can be achieved by the application of appropriately selected material.

Journal of Bioactive and Compatible Polymers, Vol. 11, No. 2, 110-121 (1996)
DOI: 10.1177/088391159601100203


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