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Journal of Bioactive and Compatible Polymers
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Enhanced Growth of Cultured Fibroblasts by a Synthetic Polyanionic Polymer

Tomohiro Sawa

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Sakyo-ku, Kyoto 606-01, Japan

Yukihisa Okumura

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Sakyo-ku, Kyoto 606-01, Japan

Junzo Sunamoro

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida-hommachi, Sakyo-ku, Kyoto 606-01, Japan

Jian L. Ding

Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284

Raphael M. Ottenbrite

Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284

A synthetic polyanionic polymer, poly(maleic acid-alt-7,12-dioxaspiro[5,6]dodec-9-ene), exhibits mitogen-like behavior for cultured fibro-blasts. Cultures of L929 and STO fibroblasts in the presence of this polymer resulted in enhanced growth by both fibroblast cell lines. After three days, at optimum polymer concentrations, the cell numbers increased 3.7-fold for the STO cells and 1.9-fold for the L929 cells compared to the cells cultured in the same environment without the polymer. The polymer promoted this growth without any other external growth factors. This result suggests that the polymer has a direct effect on the growth of both of these fibroblast cells.

Journal of Bioactive and Compatible Polymers, Vol. 11, No. 1, 17-27 (1996)
DOI: 10.1177/088391159601100102
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