This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bruneel, D. Articles by Schacht, E. Search for Related Content Social Bookmarking                         What's this?

Enzymatic Degradation of Pullulan and Pullulan Derivatives

Department of Organic Chemistry, Biomaterial & Polymer Research Group, University of Ghent, Krijgslaan 281 (S-4), B-9000 Ghent, Belgium

E. Schacht

Department of Organic Chemistry, Biomaterial & Polymer Research Group, University of Ghent, Krijgslaan 281 (S-4), B-9000 Ghent, Belgium

Pullulan was modified using three different methods: a) chloroformate activation and subsequent reaction with 2-hydroxypropylamine, b) succinoylation and c) partial periodate oxidation and subsequent reduction of the aldehyde groups. Degradation of pullulan and pullulan derivatives by -amylase, ß-amylase and lysosomal enzymes was investigated. It was observed that the rate of degradation decreased with increasing degree of chemical modification of the parent polysaccharide. The stability of pullulan and dextran was tested in serum and liver homogenate.

Journal of Bioactive and Compatible Polymers, Vol. 10, No. 4, 299-312 (1995)
DOI: 10.1177/088391159501000402


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. Hreczuk-Hirst, L. German, and R. Duncan Dextrins as Carriers for Drug Targeting: Reproducible Succinoylation as a Means to Introduce Pendant Groups Journal of Bioactive and Compatible Polymers, September 1, 2001; 16(5): 353 - 365. [Abstract] [PDF]