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Journal of Bioactive and Compatible Polymers
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Preparation and Properties of Modified Chitosan Films for Drug Release

N. Angelova

Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

N. Manolova

Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria, irashkov{at}bgearn.bitnet

I. Rashkov

Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

V. Maximova

Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

S. Bogdanova

Faculty of Pharmacy, Academy of Medicine, 1000 Sofia, Bulgaria

A. Domard

Laboratoire d'Etudes des Métariaux Plastiques et des Biomatériaux URA-CNRS 507, Université Claude Bernard Lyon I, 69622 Villeurbanne Cedax, France

A novel method of preparing modified chitosan films was developed. Bi- and tri-component chitosan films were prepared by blending chitosan with high molecular weight polyoxyethylene. The films were loaded with 8-hydroxy-7-iodoquinoline-5-sulfonic acid which was chosen as a model drug. The properties of the films were studied with respect to crystallinity, thermal stability and swelling degree. These properties were shown to depend on the ratio of polyoxyethylene/chitosan. The drug release profile from the films was measured in a buffer at pH 6.8 and 37°C. The antimycotic effect of the films against Candida albicans was determined.

Journal of Bioactive and Compatible Polymers, Vol. 10, No. 4, 285-298 (1995)
DOI: 10.1177/088391159501000401
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