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Biological Effects of Tissue Modulations in Wound Healing

Experimental Surgery I.O.R., Via di Barbiano 1/10, University of Bologna, 40100 Bologna, Italy

G. Morrone

Experimental Surgery I.O.R., Via di Barbiano 1/10, University of Bologna, 40100 Bologna, Italy

R. Giardino

Experimental Surgery I.O.R., Via di Barbiano 1/10, University of Bologna, 40100 Bologna, Italy

G. Ferioli

Institute of Histology and Embriology, Via Belmeloro 8, University of Bologna, 40100 Bologna, Italy

M. Mattioli-Belmonte

Institute of Human Morphology, Faculty of Medicine, Via P. Ranieri, University of Ancona, 60131 Ancona, Italy

S. Amati

Institute of Human Morphology, Faculty of Medicine, Via P. Ranieri, University of Ancona, 60131 Ancona, Italy

C. Tietz

Institute of Human Morphology, Faculty of Medicine, Via P. Ranieri, University of Ancona, 60131 Ancona, Italy

G. Biagini

Institute of Human Morphology, Faculty of Medicine, Via P. Ranieri, University of Ancona, 60131 Ancona, Italy

M. M. Tappa

Dermatology Clinic, L.go Cappelli 1, University of Ancona, 60100 Ancona, Italy

G. Ricotti

Dermatology Clinic, L.go Cappelli 1, University of Ancona, 60100 Ancona, Italy

The reactive and reparative capacity of injured tissue when treated with either Pulsed Electromagnetic Fields (PEMFs) or with immunomodulator drugs (Prostaglandin E2 and Thymopentin) was evaluated. A morphological and quantitative evaluation was made of the interactions and the interferences on the structural stages of tissue repair processes. When PEMFs were used the time required for new tissue to completely cover the wound was 26 days after surgery, instead of 30 days for control conditions or for treatment with PGE₂ or Thymopentin. PEMFs showed accelerated healing process. Both PGE₂ and Thymopentin should be considered, in association with other drugs, in an attempt to strengthen the various immunomodulative phases of the reconstitution of injured tissue.

Journal of Bioactive and Compatible Polymers, Vol. 10, No. 2, 85-102 (1995)
DOI: 10.1177/088391159501000201


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