Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kabanov, V. A.
Right arrow Articles by Nazarova, I. R.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Modelling of Search and Recognition for Target Cells by Protein-Linear Polyelectrolyte Conjugates

V. A. Kabanov

Division of Polymer Sciences, Department of Chemistry, Moscow State University, Moscow V-234, Russia

A. A. Yaroslavov

Division of Polymer Sciences, Department of Chemistry, Moscow State University, Moscow V-234, Russia

O. V. Boronina

Division of Polymer Sciences, Department of Chemistry, Moscow State University, Moscow V-234, Russia

S. A. Sukhishvili

Division of Polymer Sciences, Department of Chemistry, Moscow State University, Moscow V-234, Russia

I. R. Nazarova

Division of Polymer Sciences, Department of Chemistry, Moscow State University, Moscow V-234, Russia

The interaction of {alpha}-chymotrypsin covalently bound to quaternized poly(4-vinylpyridine) with oppositely charged latex particles was investigated and compared with that of free a-chymotrypsin. The free enzyme and the corresponding polymer conjugates were added to a mixture of two latexes: one coated with bovine serum albumin and the other with specific inhibitor of a- chymotrypsin. The polycations themselves were found to be nonselectively adsorbed on oppositely charged latex surfaces. However, the ca-chymotrypsin-polycation conjugates, as well as the free enzyme, were selectively adsorbed on the latex surfaces coated with the enzyme inhibitor. The results are considered to mimic the search and recognition mechanism for target cells by polyelectrolytes carrying a specific vector moiety.

Journal of Bioactive and Compatible Polymers, Vol. 10, No. 1, 41-50 (1995)
DOI: 10.1177/088391159501000105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?