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Journal of Bioactive and Compatible Polymers
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Bioactive Polymers XXXVI. Controlled Release of Cephalosporine C from Cellulosic Derivatives

Severian Dumitriu

Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600 Jassy, Romania

Marcel Popa

Polytechnic Institute of Jassy Department of Organic and Macromolecular Chemistry 23 August 11, R-6600 Jassy, Romania

Cephalosporine C was coupled onto cellulosic derivatives of N-(4-carboxy phenyl)carbamoylmethyl cellulose and crosslinked carboxymethyl cellulose to achieve controlled drug release. Starting from a mathematical model, the in fluence of certain parameters of the reaction (drug/support, activator/support molecular ratios, and reaction times) on the amount of Cephalosporine C chem ically bound to the cellulose products was determined. Evaluation of the cou pled products show extended activity by the release of Cephalosporine C by hydrolysis.

Journal of Bioactive and Compatible Polymers, Vol. 1, No. 3, 285-300 (1986)
DOI: 10.1177/088391158600100301
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