Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Bioactive and Compatible Polymers
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ikeda, T.
Right arrow Articles by Tazuke, S.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Self-Sterilizing Materials. 1. Controlled Release of Biguanide Biocides from Polymeric Materials

Tomiki Ikeda

Research Laboratory of Resources Utilization Tokyo Institute of Technology 4259, Nagatsuta, Midori-ku Yokohama, 227, Japan

Hideki Yamaguchi

Research Laboratory of Resources Utilization Tokyo Institute of Technology 4259, Nagatsuta, Midori-ku Yokohama, 227, Japan

Sigeo Tazuke

Research Laboratory of Resources Utilization Tokyo Institute of Technology 4259, Nagatsuta, Midori-ku Yokohama, 227, Japan

An acrylate monomer with a pendant biguanide, N'-4-(2-acryloyl- oxyethyl)phenyl-N5-4-chlorophenylbiguanide hydrochloride (2), when incor porated covalently into cross-linked polyacrylamide matrices was found to hydrolyzed in water to release N1-4-(2-hydroxyethyl)phenyl-N5-chlorophenylbi guanide hydrochloride (1). When the degree of cross-linking was high, the release was approximately zero-order at least over a period of one week. In con trast to 2, methacrylate and acrylamide monomers with pendant biguanide groups were strongly resistant to hydrolysis. Detailed release profiles from various cross-linked polyacrylamide films containing covalently or non- covalently bound biguanide compounds indicate that the rate of release can be tailored to specific delivery needs.

Journal of Bioactive and Compatible Polymers, Vol. 1, No. 2, 162-171 (1986)
DOI: 10.1177/088391158600100203
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?